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PETACH TIKVA, Israel, Oct. 7, 2014 /PRNewswire/ — Can-Fite BioPharma Ltd. (NYSE MKT: CANF) (CFBI.TA), a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer and inflammatory diseases, today announced the Company’s CEO, Dr. Pnina Fishman, will co-chair the Cancer Therapeutics session of the 19th World Congress on Advances in Oncology. The conference will take place in Athens, Greece, from October 9-11, 2014.

In addition to co-chairing the Cancer Therapeutics session, Dr. Fishman will deliver a presentation regarding Can-Fite’s drug, CF102, titled, “CF102 for the treatment of liver cancer: De-regulation of the Wnt signal transduction pathway.”

In pre-clinical and clinical studies in liver cancer patients, CF102 has demonstrated a robust anti-tumor effect via deregulation of the Wnt signaling pathway, known to mediate and control cell proliferation, resulting in apoptosis of liver cancer cells.

“I am grateful for the opportunity to co-chair the Cancer Therapeutics session and to present CF102 as a potential treatment for liver cancer at this prestigious international conference. This conference brings together researchers and key opinion leaders from around the world to learn about and discuss the latest developments in the fight against cancer,” stated Dr. Fishman.

CF102 is now entering Phase II trials in the U.S., Europe and Israel for the treatment of hepatocellular carcinoma, the most common form of liver cancer. The U.S. Food and Drug Administration has granted Orphan Drug Status to Can-Fite’s CF102 for this indication, and Israel’s Ministry of Health has approved CF102 for Compassionate Use in liver cancer patients.

WILMINGTON, Mass., Oct. 6, 2014 /PRNewswire/ — Implant Sciences Corporation (IMSC), a high technology supplier of systems and sensors for homeland security and defense markets, announced today that the QS-B220 has successfully passed the European Civil Aviation Conference’s (ECAC) Common Evaluation Process of Security Equipment (CEP) for airport checkpoint screening of passengers and baggage. The QS-B220 is the first Explosives Trace Detector (ETD) to pass ECAC’s stringent laboratory testing protocol. The CEP was established to provide standards for security equipment performance across ECAC’s 44 member nations. The QS-B220 was also recently added to the Transportation Security Administration’s (TSA) Qualified Products List (QPL) in the U.S.

“The 44 EU member nations covered by the ECAC approval represent an enormous opportunity for Implant Sciences. Procurements across the region have been delayed while this standard was established and implemented,” stated Implant Sciences’ Vice President of Global Sales & Marketing, Dr. Darryl Jones. “As the first company to pass the new standard, we believe we are in an excellent position to capitalize on this pent-up demand.”

“Our company has achieved an unprecedented number of ETD approvals in a very short period of time, making the QS-B220 one of the most widely approved products in the world. Implant Sciences’ success is a testament to the quality product that our design team created and our manufacturing group built,” added Glenn D. Bolduc, President and CEO of Implant Sciences. “We have been gearing up in anticipation of these approvals, and we believe that we are ready to execute on these important opportunities.”

VIENNA, Va.–(BUSINESS WIRE)–

CEL-SCI Corporation (NYSE MKT: CVM) today announced the first volunteer patient has been enrolled and administered Multikine* (Leukocyte Interleukin, Injection) in a Institutional Review Board approved Phase I Clinical Trial evaluating peri-anal wart immunotherapy in HIV/HPV co-infected men and women at the Naval Medical Center San Diego (NMCSD). The purpose of this dose escalation study is to evaluate the safety and impact of Multikine as a treatment of Human Papilloma Virus associated peri-anal warts and assess the effect on anal intraepithelial dysplasia (AIN) in HIV/HPV co-infected men and women.

The study is being conducted through a Cooperative Research and Development Agreement (CRADA) between CEL-SCI Corporation and Naval Medical Center San Diego. By entering into this CRADA, NMCSD does not directly or indirectly endorse any product or service provided, or to be provided, by CEL-SCI, its successors, assignees, or licensees. CEL-SCI is contributing doses of the investigational drug Multikine and will have the right to exclusively license a new technology developed from the collaboration.

“This is an important milestone in our Phase I trial, which is the third indication for which Multikine is being evaluated as a potential immunotherapy. We are pleased to have this working relationship with the Naval Medical Center San Diego and look forward to completing enrollment and Multikine administration for the 15 patients planned for this trial,” stated CEL-SCI Chief Executive Officer Geert Kersten.

Multikine has the potential to improve the clinical treatment of HPV lesions that are associated with cancer. The NMCSD Clinical Investigation Department has a robust spectrum of ongoing research with over 300 Institutional Review Board approved research studies and clinical trials to advance medical treatment and improving quality of life for patients.

Anal and genital warts are commonly associated with the Human Papilloma Virus (HPV), the most common sexually transmitted disease. The U.S. Center for Disease Control and Prevention (CDC) has named HPV the 4th largest health threat the U.S. will face in 2014. According to the CDC, 360,000 people in the U.S. get genital warts each year. Persistent HPV infection in the anal region is thought to be responsible for up to 80% of anal cancers. HPV is an even more significant health problem in the HIV infected population as individuals are living longer as a result of greatly improved HIV medications, but have difficulty clearing HPV due to their compromised immune system.

PETACH TIKVA, Israel, Sept. 30, 2014 /PRNewswire/ — Can-Fite BioPharma Ltd. (NYSE MKT: CANF) (CFBI.TA), a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer and inflammatory diseases, today announced the United States Patent and Trademark Office has issued a patent to the Company which covers its drug candidate, CF102, in the treatment of liver regeneration and function following liver surgery. The issued patent # 8,846,635 is titled, “Method for inducing hepatocyte proliferation and uses thereof.” Can-Fite has recently been granted a patent for this technology in Japan and the European Union.

CF102 is now entering Phase II trials for the treatment of hepatocellular carcinoma, the most common form of liver cancer in the U.S., Europe and Israel. The U.S. Food and Drug Administration has granted Orphan Drug Status to Can-Fite’s CF102 for this indication and Israel’s Ministry of Health has approved CF102 for Compassionate Use in liver cancer.

“The treatment of post-surgery liver function is an indication that would complement our current portfolio of indications in clinical trials. CF102 may offer important healing benefits for the liver not only to cancer patients, but also for patients who have other diseases or injuries of the liver,” stated Can-Fite CEO Pnina Fishman.

In preclinical studies, CF102 has induced proliferation of hepatocytes following liver resection (surgery), increased liver weight and reduced elevated levels of serum liver enzymes, reflecting improved liver status. In patients with preexisting liver diseases, such as cirrhosis or cancer, normal hepatocellular proliferation following injury is impaired, exposing patients to liver dysfunction and associated complications that can lead to liver failure and death.

Can-Fite’s intellectual property portfolio consists of 150 issued and pending patents worldwide. Additional patents relating to induction of hepatocyte proliferation and uses thereof are pending in several other markets, including Israel.

ROCKVILLE, Md., Sept. 24, 2014 (GLOBE NEWSWIRE) — Rexahn Pharmaceuticals, Inc. (NYSE MKT:RNN), a clinical stage biopharmaceutical company developing best-in-class therapeutics for the treatment of cancer, today announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation for its drug RX-3117 for the treatment of patients with pancreatic cancer. RX-3117 is a next generation, cancer-specific nucleoside analog. Rexahn is currently enrolling patients in a Phase Ib clinical trial in cancer patients and expects to complete this trial in the first quarter of 2015.

The FDA’s office of Orphan Drug Products grants orphan status to support development of medicines for rare disorders, defined as diseases that affect fewer than 200,000 people in the United States. Orphan drug designation provides Rexahn with certain benefits, including limited market exclusivity upon regulatory approval if received, exemption of FDA application fees and tax credits for qualified clinical trials.

Preclinical studies have shown that RX-3117 maintains its anti-tumor activity in human cancer cell lines that are resistant to gemcitabine, a chemotherapy drug used to treat pancreatic cancer. Gemcitabine resistance represents a major problem in the treatment of cancer patients. In pancreatic cancer patients who have been treated with gemcitabine, up to 40% of patients became resistant to gemcitabine after 30 days.

“Receiving Orphan Drug Designation for RX-3117 in the treatment of pancreatic cancer is an important milestone for this clinical development program,” commented Rexahn’s Chief Executive Officer Peter D. Suzdak, PhD. “RX-3117 has shown to be effective in treating cancer cells that have become gemcitabine resistant. If the results of our Phase Ib trial and future trials show similar results in gemcitabine resistant patients, this would represent a major breakthrough in the treatment of pancreatic cancer patients.”

MELVILLE, NY–(Marketwired – September 18, 2014) – ITUS Corporation (“ITUS”) (ITUS), a company that builds and protects innovation, today announced that its wholly owned subsidiary, Secure Web Conference Corporation (“SWCC”), filed a patent infringement lawsuit in the U.S. District Court for the Eastern District of New York against Apple Inc., in connection with SWCC’s patented Key Based Web Conferencing Encryption technology. Apple’s FaceTime video service debuted in 2010, and has been available via hundreds of millions of devices including iPhones (since the fourth generation iPhone), iPads (since the iPad 2), iPod Touches (since the fourth generation iPod), and all Macintosh desktop and laptop computers running OSX or later.

Robert Berman, ITUS’s President and CEO stated, “Our company was a pioneer in developing and patenting encryption technologies that were originally used in devices sold to the U.S. military. We recognized the monetization potential of these patents when we joined the company, and this lawsuit is the next step in realizing that potential.”

SWCC has already licensed the encryption patents to Logitech in connection with its LifeSize web conferencing service, and has a patent infringement lawsuit pending against Microsoft Corporation in connection with the SKYPE and Lync web conferencing services. A claims construction, or Markman hearing, in the Microsoft lawsuit is scheduled for September 23.

About ITUS Corporation

ITUS develops and acquires patented technologies for the purposes of patent monetization and patent assertion. The company currently has 10 patent portfolios in the areas of Key Based Web Conferencing Encryption, Encrypted Cellular Communications, E-Paper® Electrophoretic Display, Nano Field Emission Display (“nFED”), Micro Electro Mechanical Systems Display (“MEMS”), Loyalty Conversion Systems, J-Channel Window Frame Construction, VPN Multicast Communications, Internet Telephonic Gateway, and Enhanced Auction Technologies. Additional information is available at www.ITUScorp.com.

HAIFA, Israel, Sept. 16, 2014 (GLOBE NEWSWIRE) — Pluristem Therapeutics Inc. (PSTI) (TASE:PLTR), a leading developer of placenta-based cell therapy products, announced today it is evaluating strategic opportunities to co-develop and commercialize its PLacental eXpanded (PLX) cell therapies in Japan.

Recent changes in Japan’s laws governing regenerative medicine and the approval of stem cell therapies indicate the country may now offer the fastest track to commercialization in the world for regenerative medicine treatments. As part of Pluristem’s strategy in Japan, on September 16, 2014, Company executives presented to a group of Japanese pharmaceutical executives in Tokyo, and conducted a series of one-on-one meetings with Japanese companies exploring a potential partnership with Pluristem.

To support its strategy in Japan, Pluristem is working with The Sage Group, a consulting firm specializing in healthcare industry transactions and business strategy, and Sage’s partner Waterfield HealthCom, a Japan-based firm managed by Yoshi Mizuta. Mr. Mizuta is a highly experienced pharmaceutical industry executive with more than 40 years in the business of financial healthcare transactions in the Japanese arena.

Japan’s government passed a bill in 2013, which goes into effect in November of this year, effectively fast-tracking the approval of stem cell therapies for marketing. According to the law, stem cell regenerative medicine therapies can receive conditional, time-limited approval for marketing, and be eligible for reimbursement, upon proof of safety but prior to verification of efficacy; safety and effectiveness need to be confirmed after the conditional approval.

Waterfield HealthCom’s Mr. Mizuta commented, “With its broad portfolio of indications and its commercial scale 3D cell manufacturing capabilities, Pluristem is a very desirable partner for Japanese pharmaceutical companies looking to bring cell therapies to the market in the near term.”

“As a result of Japan’s favorable new law, cell therapies like Pluristem’s PLX cells can receive market approval in Japan upon completion of Phase II trials when good safety and efficacy data is available. This could potentially reduce approval time down to two or three years,” Mr. Mizuta concluded.

Pluristem CEO Zami Aberman added, “The opportunity in Japan opens an accelerated path for the global regenerative medicine industry to prove the efficacy of cell therapies in a broad patient population in Japan. Japan has one of the most advanced healthcare systems, and the second largest healthcare market in the world.”

Pluristem currently has co-development and out-licensing partnership agreements with United Therapeutics (UTHR) and South-Korea-based CHA Bio&Diostech (CHA).

PETACH TIKVA, Israel, Sept. 17, 2014 /PRNewswire/ — Can-Fite BioPharma Ltd. (NYSE MKT: CANF) (CFBI.TA), a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer and inflammatory diseases, today announced that an article titled, “New Drugs and Treatment Targets in Psoriasis,” published in the peer-reviewed scientific journal Acta Derm Venereologica, cites the Company’s CF101 as a potential treatment for psoriasis. The article was written by researchers at the Department of Dermato-allergology, Gentofte Hospital, University of Copenhagen, Denmark. To read the article in full, please visit: Acta Derm Venereologica.

The article states that biologics for the treatment of psoriasis are costly, require repeated injections, and some patients experience a loss of therapeutic effect. Thus, the development of orally available, small molecule drugs are desirable, state the article’s authors. They identify A3 adenosine receptor (A3AR) agonists as one of four potential small molecules currently in clinical trials.

The article includes a summary of Can-Fite’s Phase II psoriasis trial and includes CF101 among four small molecule drugs under development including Pfizer’s Tofacitinib, Celgene’s Apremilast, and Incyte’s Ruxolitinib.

“There is a need for small molecule orally bioavailable drugs for the treatment of psoriasis which is a chronic disease. We believe the good safety and efficacy profile that has been described in the Phase II and Phase II/III interim analysis, positions CF101 as a leading drug under development for this disease,” stated Dr. Pnina Fishman, CEO of Can-Fite.

Can-Fite’s Phase II/III psoriasis trial is ongoing with top line results expected to be released in the first quarter of 2015. The psoriasis therapeutic market was worth $3.6 billion in 2010 and is forecast to grow to $6.7 billion by 2018, according to Global Data.

MELVILLE, NY–(Marketwired – September 16, 2014) – ITUS Corporation (“ITUS”) (ITUS), a company that builds and protects innovation, today announced that its wholly owned subsidiary, J-Channel Industries Corporation (“JCIC”), has entered into a license agreement with Jeld-Wen, Inc., in connection with JCIC’s patented J-Channel Window Frame Construction technology.

Robert Berman, ITUS’s President and CEO stated, “In the past 7 days alone, we have entered into 5 revenue producing license agreements, and launched our seventh patent assertion program against eBay and the Alibaba companies. It’s amazing to see our talented team reunite, and so quickly rekindle the spark that leads to success. The momentum is beginning to build, good things are happening, and it’s an exciting time for our company and its shareholders.”

The Jeld-Wen agreement is the 12th settlement for the J-Channel Window Frame Construction technology, and resolves the patent infringement lawsuit filed against Jeld-Wen and Lowe’s on August 7, 2013, which will be dismissed.

About ITUS Corporation
ITUS develops and acquires patented technologies for the purposes of patent monetization and patent assertion. The company currently has 10 patent portfolios in the areas of Key Based Web Conferencing Encryption, Encrypted Cellular Communications, E-Paper® Electrophoretic Display, Nano Field Emission Display (“nFED”), Micro Electro Mechanical Systems Display (“MEMS”), Loyalty Conversion Systems, J-Channel Window Frame Construction, VPN Multicast Communications, Internet Telephonic Gateway, and Enhanced Auction Technologies. Additional information is available at www.ITUScorp.com.

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